HOUSTON - Hunter Pence singled home the winning run off Matt Wise in the 10th inning and the Houston Astros beat Milwaukee 5-4 Wednesday night, dropping the Brewers out of first place in the NL Central. Rickie Weeks hit a two-run homer in the ninth off Astros closer Brad Lidge to force extra innings. But the Brewers, who had won four in a row, wound up falling one game behind Chicago for the division lead -- the Cubs beat Cincinnati 3-2. Milwaukee opens a four-game series in Atlanta on Thursday night. The Cubs are idle, the host Pittsburgh over the weekend. Carlos Lee homered and hit an RBI single for the Astros, who won for just the fifth time in 18 games against Milwaukee this year. Weeks homered with one out, tying it at 4. Lidge (5-2) pitched a perfect 10th, striking out two, and got the victory. Orlando Palmeiro pinch-hit for Lidge and drew a leadoff walk from Wise (3-2) to start the 10th. Pitcher Brandon Backe pinch-ran for Palmeiro, went to second on Lance Berkman's single and dashed for third on Lee's fly out to center. Pence batted next, an inning after crashing into the right-field wall chasing Weeks' homer. Pence crumpled to the ground after the collision, but got up after a few minutes and stayed in the game. Pence fouled off the first 3-2 pitch he saw from Wise, then lined the next one into left field to bring home Backe. Prince Fielder hit his 47th homer for Milwaukee, stretching his hitting streak to 17 games. Milwaukee led 2-1 when Mark Loretta tied the game in the seventh with a two-out, RBI single off Brian Shouse. Josh Anderson, one of five rookies in the Astros lineup, led off the Houston eighth with a single and went to second on Craig Biggio's bunt. Shouse intentionally walked Lance Berkman and Milwaukee manager Ned Yost called in Derrick Turnbow to relieve. Lee then singled to score Anderson, and Pence followed with a flyout, scoring Berkman to make it 4-2. Lidge struck out Craig Counsell, but J.J. Hardy doubled. Weeks, who snapped an 0-for-16 slump with a homer on Tuesday, then drove a 3-2 pitch into the right-field seats. Weeks rounded the bases as Pence slumped to the ground. Astros trainer Rex Jones ran out to check on him, but the rookie eventually got up and stayed in the game. Juan Gutierrez, a 23-year-old rookie, made his second major-league start for Houston. Just like rookie Felipe Paulino on Tuesday night, Gutierrez ran into his trouble in the fourth inning. Fielder launched the first pitch into the balcony in left center. Corey Hart then doubled off the left-field wall, went to third on Gabe Gross' fly out and came home on Johnny Estrada's sacrifice fly to make it 2-0. Lee homered to left off Dave Bush in the Astros' fourth, his 30th of the season. Bush lasted six innings and got some help at the end of his outing from Hart, the center fielder. With two outs in the sixth, Berkman sent a deep fly ball to left-center, but Hart snagged it as he smacked into the fence to end the inning. Scott Linebrink relieved Bush for the Houston seventh and Ty Wigginton started Houston's comeback by beating out a grounder that Counsell had to backhand. Counsell replaced Braun at third base before the inning began. Wigginton went to second on a wild pitch and Linebrink walked Cody Ransom. Yost brought in the left-handed Shouse, but the pinch-hitting Loretta singled to right to score Wigginton. Notes:@ The Brewers lead the majors with 215 homers. They're one shy of the team record, set in 1982. ... Lee and Berkman both have 30 homers this year, the fifth time in team history two Astros have hit that many in the same season. ... Biggio singled in the first inning, career hit No. 3,052. He's one away from tying Rod Carew for 21st. (Copyright 2007 by The Associated Press. All Rights Reserved.)